In March 2020, the COVID-19 pandemic struck the United States. Many businesses, schools, and government agencies, including those implementing Temporary Assistance for Needy Families (TANF) programs, closed their doors. As cases began to rise across the country and staff were largely working from home, TANF program leadership and staff had to adapt to continue serving their clients. This brief explores how five of the TANF programs included in The Understanding Poverty: TANF Office Culture Study responded to the pandemic and the role that their organizational culture played in those responses.